Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis
نویسندگان
چکیده
منابع مشابه
Improving the N-terminal diversity of sansanmycin through mutasynthesis
BACKGROUND Sansanmycins are uridyl peptide antibiotics (UPAs), which are inhibitors of translocase I (MraY) and block the bacterial cell wall biosynthesis. They have good antibacterial activity against Pseudomonas aeruginosa and Mycobacterium tuberculosis strains. The biosynthetic gene cluster of sansanmycins has been characterized and the main biosynthetic pathway elucidated according to that ...
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Encrypted messages sending frequently draws the attention of third parties, perhaps causing attempts to break and reveal the original messages. Steganography is introduced to hide the existence of the communication by concealing a secret message in an appropriate carrier like text, image, audio or video. Steganography is of Greek origin and means "Covered or hidden writing". The carrier can be ...
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Polyketide biosynthetic pathways have been engineered to generate natural product analogs for over two decades. However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolites commonly results in attenuated yields or entirely inactive pathways, and the mechanistic basis for compromised production is rarely elucidated since rate-limiting or inactive domain(s) re...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2008
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.200700635